Stroke Trials & Clinical Studies at St George's

Research at St George’s

St George’s is one of the leading places in the UK for research into improving the care of stroke patients.  We are involved in many studies which explore:

• why people have strokes
• how we can treat and prevent them
• how we can improve rehabilitation.

You may be asked to participate in one or more study. We are always very grateful to patients who agree, but this is entirely voluntary.  If you are unwilling to take part it will not affect your care in any way.   The local ethics committee has to agree to all studies before they start and most are funded by organisations such as the Stroke Association.
 

A randomised, double-blind, parallel-group placebo-controlled phase lll study to evaluate the efficacy and safety of desmoteplase in subjects with acute ischemic stroke.

SO₂S – Stroke Oxygen Study

A multi-centre, prospective, randomised, open, blinded-endpoint study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome.

TARDIS - Triple Antiplatelets for Reducing

Dependency after Ischaemic Stroke

Safety and tolerability of clopidogrel when added to aspirin and dipyridamole in high risk patients with recent ischaemic stroke: a randomised controlled trial.

CADISS - Cervical Artery Dissection In Stroke Study

A multicentre randomised controlled open prospective clinical trial comparing antiplatelet therapy and anticoagulation in the acute treatment of patients with cervical artery dissection

VIST - Vertebral artery Ischaemic Stenting Trial

 A multicentre randomised controlled open prospective clinical trial comparing vertebral stenting vs. best medical treatment for symptomatic vertebral stenosis

STICH II - Surgical Trial in Lobar Intracerebral Haemorrhage

An international multicentre randomised parallel group trial comparing early craniotomy to evacuate the haematoma with initial conservative treatment, following spontaneous superficial intracerebral haemorrhage.

ENOS - The Efficacy of Nitric Oxide in Stroke Trial

A prospective, collaborative, international, multicentre, randomised, parallel-group, single and outcome blinded, controlled, factorial trial to investigate the safety and efficacy of treatment with transdermal glyceryl trinitrate, a nitric oxide donor, and of continuing or stopping temporarily pre-stroke antihypertensive therapy, in patients with acute stroke

Stroke INF

The main hypothesis for the study is that prophylactic use of antibiotics (an "act first" approach) in acute stroke patients with swallowing problems on a bedside clinical assessment will be better than the current practice of monitoring for infection and treatment if necessary (a "wait and watch" approach) in reducing chest infections and their consequences in reducing chest infections and their consequences in stroke patients.

IRIS - The Insulin Resistance Intervention

The purpose of IRIS is to determine the effectiveness of pioglitazone, compared with placebo, for prevention of recurrent stroke and heart attack among non-diabetic men and women with a recent ischemic stroke or transient ischemic attack (TIA) and insulin resistance.

Somatosensory Study

A trial to investigate whether the addition of small amounts of painless sensory stimulation in combination with specific exercise training is better than exercises alone (the current clinical practice) for improving arm function and usage in stroke patients who have stopped improving with rehabilitation.

DARS - Dopamine Augmented Rehabilitation in Stroke

Does Co-careldopa treatment in combination with routine NHS occupational and physical therapy, delivered early after stroke within a stroke rehabilitation service, improve functional recovery including walking ability and arm function?

A DNA Resource for Lacunar (Small Vessel Disease) Stroke

To establish a DNA resource of carefully phenotyped patients of lacunar stroke aged ≤70 years. Family history & additional bloods taken.

GENESIS

Identifying GENetic risk factors for cerebral small vessel disease and leukoaraioSIS.

Genetic blood samples collected. Specific time slots allocated on the T3 MRI (please request ‘genesis protocol’), Tues & Thurs 1-3pm.

GOSH – Genetics of Subarachnoid Haemorrhage

This study will investigate whether specific susceptibility loci are associated with ruptured intracranial aneurysms, and the interaction between genetic factors and aneurysm

location.

BMET

Validation of a screening tool developed to identify vascular dementia amongst patients with small vessel disease.

METB

Testing the BMET screening tool on patients with stroke not related to small vessel disease.

Research Databases

CADASIL Database

For patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy. Research bloods taken and information collected.